Research on environment effects on fertility .. 11

Research on environment effects on fertility .. 11

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Research on environment effects on fertility .. 11
Posted in 2017
First, both PCBs and a range of environmental polyhalogenated hydrocarbons (PAHs) have been shown to potently suppress activity of the enzyme oestrogen sulphotransferase (SULT1E1), through which oestrogens are inactivated. Suppression of SULT1E1 increases oestrogen bioactivity. Furthermore, in human pregnancy, when oestrogen levels are extraordinarily high, this could alter exposure of the foetus to oestrogens, a change that is established to increase risk of male reproductive disorders and function, as outlined above, and may also affect the risk of breast cancer in females. Human exposure to PCBs and to PAHs is widespread. There is also the possibility of polymorphisms in genes such as the oestrogen sulphotransferases, which may produce changes in enzyme activity that might indicate inter-individual differences in inherent or chemically induced susceptibility to oestrogen-related disorders.
Second, male rats exposed in utero to certain phthalate esters that were administered to their mothers exhibit a high frequency of cryptorchidism, hypospadias and abnormal testes, associated with suppression of testosterone levels in the foetal testis,. These changes are remarkably similar to the changes in human male reproductive health mentioned above, and which can be induced by over-exposure to oestrogens. Phthalate esters have multiple and varied uses (for example, as plasticizers and spreading agents) and are the class of environmental chemicals to which there is greatest (and universal) human exposure. Though the doses of phthalates required to induce high prevalence of these disorders in rats is considerably higher than humans are exposed to, a recent study has identified a small sub-group of the general population who have unusually high exposure to phthalates, these being predominantly women of reproductive age.
Third, exposure of humans to DDT is associated with an increased incidence of IUGR and a mild increase in the incidence of hypospadias and cryptorchidism. This is consistent with the demonstration that the main metabolite of DDT is a potent anti-androgen that blocks the androgen receptor and induces these abnormalities in animals.



 My advise
1....  Our environment plays major role on our health including fertility
2....  We are using cell phones which emit radiation and decreases fertility in male n female
3...   The persons working in chemical industries or residing near to chemical industries decreases their fertility
4....  Pollution also negatively effect on fertility
5....  If you are working in chemical industries tell your management to put small plants around the industries will to get fresh oxygen which nullify negative effect on your health.. 
6....  Put small plants in your house to get fresh oxygen
7...   Leave smoking, alcohol, ghutka .............habits
8...   As possible as stay away from cell phone as cell phone radiation will diminish your sperm or eggs quality


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